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【摘要】 目的 探讨体外冲击波碎石(ESWL)治疗较大输尿管下段结石术后应用坦索罗辛，对于提高结石清除率的有效性与安全性。方法 应用随机对照的临床试验方法，对80例较大输尿管下段结石(直径大于10 mm)的患者进行了为期4周的观察，在接受首次ESWL治疗后，对照组(n=40)接受保守治疗，治疗组(n=40)除保守治疗外，每日服用坦索罗辛0.4 mg。结果 首次ESWL后2周随访末，治疗组的结石清除率(82.5%，33/40)显著高于对照组(52.5%，21/40)(P 4 结论�
应用高选择性α��1A/D肾上腺素能受体抗结剂坦索罗辛(每日0.4 mg)，可以显著提高ESWL治疗较大输尿管下段结石的成功率及治疗效率。在4周的临床应用中不良反应轻微。而且坦索罗辛结合保守治疗可以减轻ESWL术后结石碎片引起的绞痛。因此，建议在ESWL治疗较大(10 mm以上)输尿管下段结石的过程中，应用坦索罗辛作为ESWL术后辅助治疗。�
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