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【摘要】 目的 探讨幽门螺杆菌阴性消化性溃疡并发出血的危险因素。方法 对138例幽门螺杆菌阴性消化性溃疡的影响因素采用病例-对照研究的方法。117例发生并发症出血。研究项目包括:性别、年龄、吸烟史、饮酒史、腹痛、休克表现、高血压、冠心病、糖尿病、服用非甾体抗炎药情况、心理因素、伴随疾病、溃疡情况、血脂异常、凝血功能异常、血小板计数、血红蛋白值。 结果 单因素分析显示无腹痛(P=0.003)、有休克表现(P=0.004)、伴随疾病者(P=0.005)、溃疡活动期(P=0.003)有统计学意义;进行Logistic回归模型多因素分析显示:无腹痛、有休克表现、伴随疾病者、溃疡活动期有统计学意义(P 表1
138例H.pylori阴性PU是否并发出血的
临床资料比较(例)
项目并发出血未并发出血χ2P值
年龄(岁)1004111
血红蛋白�(g/L)≤1207392.8180.093
>1204412
注:#P [2] Howden CW,Leontiadis GI.Current indications for acid suppressants in Helicobacter pylori-negative ulcer disease.Best Pract Res Clin Gastroenterol,2001,15(3):401-412.
[3] Xia HH,Wong BC,Wong KW,et al.Clinical and endoscopic characteristics of non-helicobacter pylori,non-NSAID duodenal ulcers:a long-term prospective study.Aliment Pharmacol Ther,2001,15(12):1875-1882.
[4] Liu NJ,Lee CS,Tang JH,et al.Outcomes of bleeding peptic ulcers:a prospective study.J Gastroenterol Hepatol,2008,23(8 Pt 2):e340-347.
[5] Grinevich VB,Uspenskii IuP,Shabanova GZh,et al.Characteristcs of non-Helicobacter pylori ulcer disease.Ter Arkh,2002,74(2):24-27.
[6] Ramsoekh D,van Leerdam ME,Rauws EA,et al.Outcome of peptic ulcer bleeding,nonsteroidal anti-inflammatory drug use,and Helicobacter pylori infection.Clin Gastroenterol Hepatol,2005,3(9):859-864.
[7] Rodriguez-Hernandez H,Rodriguez-Moran M,Gonzalez JL,et al.Risk factors associated with upper gastrointestinal bleeding and with mortality.Rev Med Inst Mex Seguro Soc,2009,47(2):179-184.
[8] Elitsur Y,Lawrence Z.Non-Helicobacter pylori related duodenal ulcer disease in children.Helicobacter,2001,6(3):239-243.
[9] Gisbert JP,Legido J,Castel I et al.Risk assessment and outpatient management in bleeding peptic ulcer.J Clin Gastroenterol,2006,40(2):129-134.