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【摘要】 目的 观察Her-2/neu过表达的乳腺癌患者对不同辅助化疗方案的敏感性。方法 选取2002年5月至2005年8月在我院乳腺中心接受手术且术后辅助化疗的原发性乳腺癌患者Her-2过表达者共134例,分别采用蒽环类或紫杉类方案化疗,中位随访时间38个月,分析她们的临床特征和病理学特征,不同化疗方案对无病生存期的影响。结果 Her-2过表达(++、+++)者134例,占27.7%,采用CAF方案化疗者77例,含紫杉类化疗者57例,采用CAF方案复发转移31.2%(24/77),无病生存率68.8%,含紫杉类复发率14.0%(8/57),无病生存率86%,χ�2=5.290,P10%的肿瘤细胞膜观察到淡的或较难觉察的着色,细胞的部分细胞膜着色为Her-2过表达阴性,评分为+;>10%的肿瘤细胞全部的细胞膜存在弱至中等强度的着色为Her-2过表达弱阳性,评分为++;>10%的肿瘤细胞全部的细胞膜存在高强度的着色为Her-2过表达强阳性,评分为+++。
2 结果
记录所有患者的临床病理特征和化疗方案,共483例,其中Her-2过表达(++、+++)134例,Her-2过表达占27.7 %,采用CAF方案化疗者77例,含紫杉类化疗者57例,采用CAF方案复发转移24例,占31.2%,含紫杉类8例,占14.0%,χ�2=5.290,P 参 考 文 献
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