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【摘要】 目的 探讨肺动脉高压与甲状腺疾病的关系。方法 回顾性分析了214例肺动脉高压患者和200例对照组患者合并甲状腺疾病的发病率。结果 肺动脉高压的患者中WHO1型和2、3、4型患者的血清TSH水平均明显高于对照组患者的TSH水平(P0.05)。WHO1型与2、3、4型患者中合并甲状腺疾病的差异无统计学意义(P0.05). There was no significant difference of the prevalence of thyroid diseases between WHO type 1 and type 2, 3, 4 patients (P 但是肺动脉高压合并甲状腺疾病的机制目前尚不明确。可能与以下因素相关:(1)自身免疫反应导致血管内皮损伤及功能紊乱;(2)高循环血流动力学状态导致血管内皮损伤;(3)肺血管舒张因子代谢增加等,均可导致肺血管舒张因子生成减少或破坏增加,诱发并加重肺动脉高压[10,11]。并且肺动脉高压和甲状腺功能减退与多种自身免疫性疾病相关,提示肺动脉高压合并甲状腺功能减退的发病机制可能与自身免疫性病理生理因素相关[12]。�
综上所述,肺动脉高压患者常合并甲状腺疾病,因此有必要对肺动脉高压的患者常规进行甲状腺功能的检查。并且,仍需要进一步的研究以探讨肺动脉高压合并甲状腺疾病的发病机制。�
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