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【摘要】目的：探讨了糖尿病肾病患者治疗前后血浆内皮素和血管内皮生长因子水平的变化和意义。方法：分别应用放免法和Elisa法对69例糖尿病患者进行了血浆 ET和VEGF水平测定，并与35名健康人作比较。结果：在治疗前血浆ET和VEGF水平非常显著的的高于正常人组（P
参考文献
[1]刘力生.临床高血压学.第1版天津科学技术出版社，1999,112.
[2]董晓辉，陈潘藻.血管内皮生长因子的检测和临床意义.标记免疫分析与临床.
[3]Kohan DE.Endothelins in the kidney:Physiology and psthophysiology.Am J kidney,1993,22(4):493.
[4]王秋月，刘国宏，王春义，等.早期糖尿病肾病患者血浆内皮素，血纳素，血管紧张素Ⅱ的变化及意义.这中国实用内科学杂志，1998,18（12）：722.
[5]Simon M,Rockl W,Hornig C,et al.Receptors of vascular endothelial growth factor/vascular permeability factor(vegf/vpf)in fetal and adult human kidney:localization and (125I)VEGF binding dites.J Am Soc Nephrol,1998,9(10):1032.
[6]Simon M,Grone HJ,Johren O,et,al.Expression of vascular endothelial growth factor and its receptiors in human renal ontogensis and in adult kidney.Am J Physiol,1995,268(1):7240.
[7]周智，扬义明，李艳，等.血浆血管生长因子及血管紧张素Ⅱ与糖尿病肾病的关系.中国病理生理杂志，2002，，18（5）：551.
[8]Kim NH,Jung HH,ChaDR,et al.Expression of vascular endothelial growth factor in respose to high glucose in rat mesangial cells.J Endocrinol,2000,165(3):617.
[9]Cooper ME,Vranes D,Youssef S,et,al.Increased renal expression of vascular endothelial growth factor(VEGF)and VEGFR-2 inexperimental diabetes.Diabetes,1999,48(11):2229.
[10]卢小卓，方锦鎏.糖尿病肾病患者治疗前后AT-Ⅱ，VEGF，ET和ANP水平的变化.放射免疫学杂志，2003,16（4）：200.
[11]Ame,miya T,Sasamura H,Mifune M,et,al.Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells.Kidney Int,1999,56(9):2055.
