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[摘要] 目的 分析鼻腔NK/T细胞淋巴瘤的疗效及预后因素。方法 分析1996年9月～2005年9月本院收治的60例Ⅰ/Ⅱ期鼻腔NK/T细胞淋巴瘤资料。单因素分析采用Kaplan-Meier法,多因素分析运用Cox比例风险模型。结果 全组5年总生存率(OS)和无病生存率(DFS)分别为56.4%与38.6%。达CR与未达CR的5年OS率分别为60.4%及16.0%(P0.05),5年DFS分别为57.0%及51.4%(P>0.05)。放疗后化疗和化疗后放疗的5年OS率及DFS率分别为59.2%及52.6%,和53.6%及47.5%,无统计学意义。多因素分析显示,B症状、CR率、超腔为独立预后因素。结论 单纯化疗在早期鼻腔NK/T细胞淋巴瘤疗效差。B症状,超腔,CR率是判断预后的指标。
[关键词] NK/T细胞淋巴瘤;放射治疗;化学治疗;预后
[中图分类号] R739.62[文献标识码] A [文章编号] 1673-9701(2010)04-06-03
Prognostic Factors and Curative Efficacy of Nasal NK/T-cell Lymphoma
LUO YangkunTAN YanFU BinyuWEN Hao
Radiation Therapy Center,Sichuan Provincial Tumor Hospital,Chengdu 610041,China
[Abstract] Objective To analyze the curative efficacy and prognostic factors in 60 cases of primary nasal NK/T-cell lymphoma. Methods From Sept.1996 to Sept.2005, 60 cases of nasal NK/T-cell lymphoma were diagnosed pathologically. Data from these patients were reviewed. Kaplan-Meier methods were applied in single-factor analysis,and the Cox regression model was applied in multivariate analysis. Results The 5-year overall survival(OS)rate and disease free survival(DFS)rate for all patients were 56.4% and 38.6%. The 5-year OS rate for CR and no-CR patients was 60.4% and 16.0%(P60岁13例,中位年龄45岁。Ann Arbor分期:Ⅰ期38例,Ⅱ期22例。28例有B症状。PS评分 2结果
2.1近期疗效
全组患者中达CR30例(50%)。单纯放疗5例达CR(5/7),单纯化疗1例CR(1/16),放疗后化疗11例达CR(11/17),化疗后放疗13例达CR(13/20)。单纯放疗及综合治疗CR率明显高于单纯化疗(P0.05),5年DFS分别为57.0%及51.4%(P>0.05)。放疗后化疗和化疗后放疗的5年OS率及DFS率分别为59.2%及52.6%,和53.6%及47.5%,无统计学意义。
2.3预后因素分析
单因素分析PS评分(P
