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[摘要]目的评价术前服用非那雄胺和术中使用立止血对经尿道前列腺切除术(TURP)术的影响。方法采用随机对照试验,将拟行TURP 术的BPH 患者随机分为A组术前非那雄胺组(5mg/d×2w)、B组术中立止血组(1ku iv+1ku im)、C组术前非那雄胺联合术中立止血组及D组对照组,每组30例。记录各组TURP前列腺切除重量、术中失血量,电切操作时间,以及术后连续膀胱冲洗时间,并进行统计学分析。结果A、B、C、D组前列腺组织平均手术切除量分别为(19.4±7.9)g、(20.3±8.)6g、(19.3±6.7)g、(21.2±5.4)g,统计学分析四组之间无显著差异(P>0.05)。术中平均出血量分别为(170.5±86.4)mL、(163.4±73.4)mL、(137.0±68.2)mL、(245.1±168.9)mL,术后连续膀胱冲洗时间平均为(49.4±10.5)h、(51.9±14.6)h、(41.4±9.5)h、(52.7±16.9)h,经统计学分析,A组、B组在术中平均出血量上没有差异(P>0.05),都与D组有显著性差异(P0.05);对于这两个方面,C组与另三组均有显著性差异(P0.05);在术中平均出血量,A组、B组在两项指标上没有差异(P>0.05),但都与D组有显著性差异(P 因此,我们认为联合术前口服非那雄胺和术中立止血应用对减少TURP术中术后出血有良好效果,增加了手术操作的安全性,促进患者的早期恢复,同时还可避免了由于术后止血药的应用出现的血栓性疾病。
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(收稿日期:2009-03-24)
