【www.zhangdahai.com--班主任工作总结】
摘 要目的：研究生长激素缺乏症(GHD)儿童用生长激素治疗前后的骨代谢指标的改变。方法：测定32例生长激素缺乏症(GHD)儿童应用生长激素治疗前、治疗3个月、治疗6个月和35例年龄、性别匹配的正常健康儿童的血清骨钙素(OC)、I型胶原交联羧基末端肽(ICTP)比较各组差异。结果：GHD治疗前组血清OC、ICTP均显著低于正常对照组(P 总之，GHD儿童体内骨转换水平明显降低，儿童期骨量储备不足是导致成年后骨质疏松及骨折发病率明显增高的原因，rhGH替代治疗可促进骨形成和骨吸收的明显加速，维持GHD儿童体内骨代谢正常水平，是预防骨质疏松的有效途径，值得临床重视。
参考文献
[1] 萍玉.儿童骨密度的研究进展 国外医学妇幼保健分册,2002;13(3):138
[2] Bodine P V,Komm B S.Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor［J］.Bone,1999,25(5):535-536.
[3] ASSEM M,MOSEKLDEL,ERIKSENEF.Growth homone stimulaties proliferation of normal human bone marrow stromai osteoblast precursor cells in vitro ［J］.Growth Regnl,1994,4(1):131-135.
[4] CH HARA K,SUGMOTO T.The action of GH/IGF1/IGFBP in osteoblasts and osteoclass ［J］.HormRes,,1997,48(Supp1 5):45-49.
[5] NISHIYAMAK,SUGMOTOT,KAJIH,et al Stimutatory effect of growth homone on bone resorption and osteoclast differentiation［J］.Endocrinology,1996,137(1):35-41 .
[6] National Osteoporosis Foundation.Osteoporosis:review of the evidence for prevention,diagnosis and treatment and cost-effectiveness analysis ［J］.Osteoporos Int,1998.8(Supp1 4):S1-S88.
[7] RIZZOL IR,BONJOUR J P.Determ inants of peak bone mass and mechanisms of bone loss ［Osteoporos Int,1999,9(Supp1 2):S17-S23.
[8] KORANYIJ,SVENSSON J,GO THERSTROM G,et al Baseline characteristics and the effects of five years of GH replacement ent therapy in adults wich GH deficiency of childhood or adulthood onset:A comparative,prospective study［J］. Clin Endocrino lMetab,2001,86(10):4693-4699.
