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[摘要] 目的 通过实验观察化痰五味散对慢性支气管炎模型的作用。方法 采用豚鼠组胺引喘实验、豚鼠离体气管条实验、小鼠二氧化硫引咳实验及抗炎实验,对化痰五味散的平喘、止咳、抗炎作用进行实验研究。结果 化痰五味散可明显延长引喘潜伏期,对组胺引起的豚鼠离体气管条收缩具有较好的抑制作用,明显延长二氧化硫所致小鼠的咳嗽潜伏期,具有改善慢性支气管炎性病变的作用。结论 化痰五味散具有明显平喘、止咳、抗炎作用,可用于慢性支气管炎的治疗。
[关键词] 化痰五味散;慢性支气管炎模型;实验研究
[中图分类号] R562.1+1;R285.5[文献标识码] A [文章编号] 1673-9701(2010)04-35-02
Effect of Expectorant Wuwei Pulvis on Chronic Bronchitis:An Experimental Study
BAI Xuhua1WANG Hongtao2ZHAO Zhonghua1BAO Guilan1WANGYuying1LIU Mingjie1YU Lijun1 QiIANG Xin1
1. College of Medicine of Inner Mongolia Univercity for Nationalities,Tongliao 028041,China; 2. Liaohe Town Animal Quarantine Station,Tongliao 028000,China
[Abstract] Objective To investigate the effects of expectorant Wuwei pulvis on chronic bronchitis. Methods An experimental study was made of the antitussive and antiasthmatic and anti-inflammatory effects of expectorant Wuwei Pulvis by using guinea pig histamine experiments,guinea-pig isolated tracheal strips in vitro experiments,mouse experiments of sulfur dioxide cited cough and anti-inflammatory experiments. Results The expectorant Wuwei pulvis could obviously prolong the latent period of asthma and had the significant inhibition of the contraction of guinea-pig isolated tracheal strips induced by histamine.It could obviously prolong the latent period of mouse cough induced by sulfur dioxide and had the improvement of inflammatory lesions of chronic bronchitis. Conclusion The expectorant Wuwei pulvis has significant antiashmatic,antitussive and anti-inflammatory effects,and can be used in the treatment of chronic bronchitis.
[Key words] Expectorant Wuwei pulvis;Chronic bronchitis models;Experimental studies
化痰五味散为蒙医临床常用药,由沙棘膏、栀子、木香、甘草、白葡萄干五味蒙药制成,具有清热祛痰,止咳定喘功效。临床主要用于肺热久嗽,喘促痰多,胸中满闷,胸胁作痛;急、慢性支气管炎见上述证候者[1]。为了阐明其疗效的理论基础,我们对此进行了平喘、止咳、抗炎作用的实验研究,为临床用药提供依据。
1材料
1.1动物
昆明种SPF级小鼠,体重(20±2)g,豚鼠,体重(180±20)g,雌雄各半,均由内蒙古民族大学动物室提供。
1.2药物
化痰五味散,由内蒙古民族大学附属医院提供,批号:071213;氨茶碱片,石家庄市中山制药厂,批号:050922;磷酸可待因,青海制药厂有限公司,批号:041213;地塞米松片,天津药业集团有限公司,批号:020618。
1.3仪器
CC2170A型恒压超声雾化器(中外合资成都维信电子科大新技术有限公司);BL-420E生物信号分析系统(成都泰盟);荧光显微镜(上海)。
1.4统计学处理
实验数据以(χ±s)表示,采用SPSS统计软件进行统计学处理。以P
