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[摘要] 目的:观察拟中药汤结合常规西药治疗反流性食管炎的临床疗效及安全性。方法:选择2007年4月～2009年10月在本院就诊并诊断为反流性食道炎的患者64例,全部患者随机平分为治疗组和对照组。对照组给予常规西药治疗,治疗组在此基础上加用自拟中药汤治疗。结果:本文治疗组总有效率为93.8%,对照组为78.1%,治疗组疗效明显优于对照组,两组都无明显不良反应。结论:中西医结合治疗反流性食管炎,具有促进胃肠动力恢复、影响胃肠激素分泌等作用,值得临床推广。
[关键词] 反流性食管炎;中西医结合治疗
[中图分类号] R856.5 [文献标识码]A [文章编号]1674-4721(2010)04(a)-016-02
Clinical advantages of combination of Chinese and Western medicine treatment in reflux esophagitis observation
CHEN Zhongqin,KANG Jianhua,LIANG Jingqiang
(Wangniudun Hospital of Dongguan, Dongguan 523200, China)
[Abstract] Objective: To observe the clinical efficacy and safety of chinese combined with conventional western medicine in reflux esophagitis. Methods: 64 cases of reflux esophagitis diagnosed in our hospital from April 2007 to October 2009.All patients were randomly divided into treatment group and control group.Control group was given conventional western medicine treatment,the treatment group was added on that basis with the chinese medicine. Results: In treatment group,the total efficiency was 93.8%,control group was 78.1%,treatment group significantly better than the control group.There was no side effects in the two groups. Conclusion: Combination of chinese and western medicine treatment of reflux esophagitis can affect the gastrointestinal hormone secretion,increase lower esophageal sphincter tension,improve the esophageal mucosal defense capability,so in the treatment of reflux esophagitis has achieved good effect in clinical work.
[Key words] Reflux esophagitis;Combination of chinese and western medicine treatment
反流性食管炎属于祖国医学“吐酸”、“胸痹”、“胃痛”等病范畴,主要是由于情志不畅、外邪内袭、饮食停滞等因素,导致脾胃升降失调,加之肝失疏泄,使胃失和降所造成[1]。本文在总结多年临床经验,针对其主要病因病机,在传统西药治疗的基础上,自拟中药汤治疗本病,取得较好的临床效果。现分析报道如下:
1 资料与方法
1.1 一般资料
根据参考文献[2]中的标准,本研究共纳入64例患者,均来源于2007年4月～2009年10月在本院专科门诊的患者,随机平分为两组。治疗组32例,其中,男20例,女12例;年龄最小25岁,最大68岁,平均(49.5±6.6)岁;最短病程3个月,最长2年,平均(9.8±5.1)个月。对照组32例,男19例,女13例;年龄最小27岁,最大67岁,平均(48.5±7.1)岁;最短病程4个月,最长1.5年,平均(9.5±7.2)个月。两组一般资料经t检验,差异无统计学意义(P>0.05),具有可比性。
1.2 治疗方法
对照组:口服奥美拉唑肠溶片20 mg,每日2次,早晚空腹服用。多潘立酮(吗丁啉),每次10 mg,每日3次,饭前30 min口服。治疗组:在对照组治疗的基础上应用自拟中药汤,组方如下:法半夏15 g,黄芩12 g,黄连5 g,柴胡6 g,枳实10 g,党参12 g,陈皮6 g,茯苓12 g。按传统中药煎服法,上药水煎2次,共取汁500 ml,每日1剂,分2次早晚饭后1 h服用。两组治疗8周为1个疗程,疗程结束后1周内评价疗效,同时观察服用本药后有无不适感,并结合血、尿、大便常规和肝肾功能检查,观察本药有无毒副作用。
1.3 疗效标准
采用参考文献[2]中的疗效标准。
1.4 统计学方法
采用SPSS 15.0统计软件,计数资料采用χ2检验,计量资料采用t检验,P
