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【摘要】目的观察肿甲地孕酮分散片辅助止吐30例疗效观察 。方法将36例化疗晚期肿瘤患者随机分成对照组和观察组各18例。对照组单用化疗；治疗组化疗加甲地孕酮。化疗前1天开始服用甲地孕酮160 mg，1次/天直至化疗结束后7 天;对照组单用化疗，2个周期化疗后观察两组患者化疗后胃肠道反应、食欲、体重、骨髓抑制情况、karnofsky评分情况。结果经2个周期化疗后，观察组在胃肠道反应、食欲、体重、karnofsky评分方面均有明显改善。1例出现血糖升高， 1例双下肢水肿，经对症处理症状均消失。结论甲地孕酮毒副反应轻，对化疗期间改善患者的生活质量、减少化疗毒副反应有明显帮助，值得临床推广运用。
【关键词】化疗; 辅助止吐; 甲地孕酮; 疗效观察
Cancer patients taking megestrol acetate combined with chemotherapy in 36 cases
【Abstract】Objective To observe the swelling of megestrol acetate tablet auxiliary antiemetic 30 cases. Methods 36 patients with chemotherapy for advanced cancer were randomly divided into control group and observation group of 18 cases. Control group, chemotherapy alone; chemotherapy treatment group megestrol. 1 day before chemotherapy began taking megestrol acetate 160 mg, 1 times / day until 7 days after chemotherapy; control group, chemotherapy alone, two cycles of chemotherapy after chemotherapy were observed after gastrointestinal reactions, loss of appetite, weight, bone marrow inhibition, karnofsky score situation. Results After 2 cycles of chemotherapy, the observation group in the gastrointestinal tract reactions, loss of appetite, weight, karnofsky scores were significantly improved terms. 1 patient had elevated blood sugar, and 1 lower extremity edema, symptoms disappeared after symptomatic treatment. Conclusion The toxicity of Megestrol light on the life of patients during chemotherapy improve quality and reduce the toxicity of chemotherapy has significantly helped, is worthy of clinical use.
【Key words】chemotherapy; assisted antiemetic; megestrol acetate; efficacy
恶心、呕吐是癌症患者化疗中常见的副反应，严重的胃肠道反应影响了化疗的正常进行。甲地孕酮可改善改善肿瘤病人化疗期间的食欲等。2008年1月至2009年12月收治的肿瘤病人服用甲地孕酮配合化疗，在减轻化疗不良反应方面疗效满意，现将情况报道如下。
1资料与方法
1.1 一般资料 病例选自我组2008年1月至2009年12月收治的肿瘤病人36例，均确诊， karnofsky评分>60分。其中，男22例，女14例，年龄最大的77岁，年龄最小的33岁，中位年龄57岁。按癌症分类：肺癌12例，乳腺癌9例，大肠癌7例，食道癌6例食管癌2例。随机分为对照组(单纯化疗)和观察组（化疗加甲地孕酮）各18例，两组在年龄、性别、病症、病史、KPS评分方面均无显著性差异，具有可比性。
1. 2方法所有患者均选用以顺铂为主的化疗方案，同种疾病对照组与观察组化疗方案相同。观察组化疗前1 d开始用甲地孕酮，其余用药对照组。2个周期化疗结束后分别观察2组患者治疗后食欲改善、KPS评分、体质量、不良反应情况。
1. 3疗效评定不良反应按WHO急性毒性分级标准进行评价。
1. 4统计学方法计数资料以率(% )表示，采用χ2检验，以P
