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[摘要] 目的 探讨左旋氨氯地平对不稳定型心绞痛(UAP)的临床疗效。方法 采用随机、单盲、对照研究;236例UAP患者随机分为左旋氨氯地平治疗组(118例)和常规治疗组(118例)。左旋氨氯地平治疗组:在常规治疗基础上加用左旋氨氯地平,2.5mg,每日1次,共4周;常规治疗组:消心痛10mg/次,3次/d。结果 左旋氨氯地平治疗组总有效率89.83%和83.90%,显著高于常规治疗组的71.19%和63.56%;无严重不良反应。结论 左旋氨氯地平可以有效地治疗不稳定型心绞痛。
[关键词] 不稳定型心绞痛;左旋氨氯地平;临床研究
[中图分类号] R541.4[文献标识码] A [文章编号] 1673-9701(2009)36-147-02
Levamlodipine for Unstable Angina Pectoris
WANG Qizhu
Affiliated Hospital of Shandong Medical College,Linyi 276004,China
[Abstract] Objective To investigate the clinical efficacy of levamlodipine for the treatment of unstable angina pectoris(UAP). Methods A randomized,single blind,controlled study was carried out in 236 cases of UAP which were randomly divided into levamlodipine treatment group (118 cases) and conventional treatment group(118 cases). Levamlodipine,2.5mg,once a day for 4 weeks was given to the levamlodipine treatment group on the based of conventional therapy. The conventional treatment group was given isosorbide dinitrate 10mg/time,3 times/day. Results The total effective rates in the levamlodipine treatment group were 89.83% and 83.9% with no adverse reactions,significantly higher than those of the conventional treatment group(71.19% and 63.56%). Conclusion Levamlodipine can be used for effective treatment for unstable angina pectoris.
[Key words] Unstable angina pectoris;Levamlodipine;Clinical research
不稳定型心绞痛是冠心病一种常见的类型。钙离子拮抗剂是冠心病的常用治疗药物,短效钙离子拮抗剂因其半衰期短,药理作用时间短,对心肌缺血不利,甚至于会增加心肌梗死的发生率,不能单独应用于冠心病的常规治疗。但是长效制剂左旋氨氯地平因其特殊的化学结构,显示出冠心病治疗的良好药理学效应。我们应用左旋氨氯地平治疗不稳定性心绞痛的临床研究,现报道如下。
1对象与方法
1.1 对象
将确诊为不稳定型心绞痛的236例患者随机分为两组。治疗组118例,男75例,女43例;年龄32～73岁(平均56.8岁),病程1～19年(平均4.7年)。对照组118例,男74例,女44例;年龄35～71岁(平均52.7岁),病程1～18年(平均5.1年)。两组临床资料基本相同,具有可比性。
1.2方法
对照组采用常规治疗(含镁极化液300mL,消心痛10mg/次,3次/d,肠溶阿司匹林片75mg,晨起1次顿服)。适当加用β-受体阻滞剂,心绞痛发作时含服硝酸甘油0.3～0.6mg。治疗组在常规治疗基础上加用左旋氨氯地平(施慧达苯磺酸左旋氨氯地平片,吉林天风制药)2.5mg,1次/d,口服,治疗4周。用药前后观察心绞痛发作频率、程度、持续时间、心电图变化及不良反应出现情况。
1.3疗效判断
(1)显效:心绞痛发作减少≥80.0%,硝酸甘油用量减少>80.0%,ST段恢复正常;(2)有效:心绞痛发作及硝酸甘油用量减低50.0%～80.0%,ST段压低回升0.5mm以上;(3)无效:心绞痛发作与硝酸甘油用量减少
